Role of multiple antibiotic efflux pumps in the removal of cellular metabolites

Bacteria resistant to multiple antibiotics are one of the major challenges to public health worldwide. Bacterial pumps capable of effluxing multiple antibiotics out of cells are major contributors to this problem, and are also involved in virulence. These pumps are present in all bacteria, and are well conserved in many cases. AcrAB>TolC is the main multidrug efflux in Escherichia)coli and many other important patho...